Prof. Dr. Levent R. BÜYÜKUYSAL - UÜTF Tıbbi Farmakoloji Anabilim Dalı

Akademik Kadro - Prof. Dr. Levent R. BÜYÜKUYSAL

Pozisyonu

Prof. Dr. Levent BÜYÜKUYSALProfesör
Uludağ Üniversitesi Tıp Fakültesi
Farmakoloji ve Klinik Farmakoloji Anabilim Dalı
Görükle Kampüsü, Bursa, 16059


Tel : +90 (224) 295 3562
Faks : +90 (224) 442 81 02
Email: lrbuyuk@uludag.edu.tr

 

İLGİLENDİĞİ ARAŞTIRMA ALANLARI

  • Nörofarmakoloji
  • Nörokimya

 

Üyelİklerİ

  • Türk Farmakoloji Derneği

 

YABANCI DİL

  • İngilizce

 

ÖDÜLLERİ

  • (1986) NOVARTIS Farmakoloji Dalı Araştırma Ödülü
    Birincilik Ödülü

 

BAŞLICA YAYINLARI

  1. Ulus I.H., Millington W.R., Büyükuysal R.L. and Kiran B.K. (1988) Choline as an agonist. Determination of its agonistic potency on cholinergic receptors. Biochemical Pharmacology 37, 2747-2755.
  2. Büyükuysal R.L. and Wurtman R.J. (1989) Tetrahydroaminoacridine but not 4-aminopyridine inhibits high-affinity choline uptake in striatal and hippocampal synaptosomes. Brain Research 482, 371-375.
  3. Büyükuysal R.L. and Wurtman R.J. (1990) 4-Aminopyridine increases acetylcholine release without diminishing membrane phosphatidylcholine. Journal of Neurochemistry 54, 1302-1309.
  4. Wurtman RJ, Blusztajn JK, Ulus IH, Coviella IL, Buyukuysal RL, Growdon JH, Slack BH (1990) Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases. Adv. Neurol., 51: 117-125.
  5. Büyükuysal R.L. Holmes T.C. and Wurtman R.J. (1991) Interactions of 3,4-diaminopyridine and choline in stimulating acetylcholine release and protecting membrane phospholipids. Brain Research 541, 1-6.
  6. Farber S.A., Büyükuysal R.L. and Wurtman R.J. (1991) Why do phospholipid levels decrease with repeated stimulation? A study of choline containing compounds in rat striatum following electrical stimulation. in Aging and Alzheimer's Disease: Sensory systems, neuronal growth and neuronal metabolism. Proceedings of the sixth meeting of the international study group on the pharmacology of memory disorders associated with aging, p. 603-606, Zurich Switzerland.
  7. Ulus I.H., Büyükuysal R.L. and Wurtman R.J. (1992) N-Methyl-D-aspartate increases acetylcholine release from rat striatum and cortex: Its effect is augmented by choline. The Journal of Pharmacology and Experimental Therapeutics 261, 1122-1128.
  8. Büyükuysal R.L., Ulus I.H., Aydin S., Kiran .B.K. (1995) 3,4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatum. European Journal of Pharmacology 281, 179-185.
  9. Büyükuysal R.L. (1997) Effect of nitric oxide donors on endogenous dopamine release from rat striatal slices 1: Requirement to antioxidants in the medium. Fundamental and Clinical Pharmacology, 11, 519-527.
  10. Büyükuysal R.L. (1997) Effect of nitric oxide donors on endogenous dopamine release from rat striatal slices 2: The role of voltage-dependent sodium channels, calcium channel activation, reverse transport mechanism, guanylate cyclase and endogenous glutamate. Fundamental and Clinical Pharmacology, 11, 528-536.
  11. Büyükuysal R.L., Ulus I.H. and Kiran B.K. (1998) Age-related alterations in presynaptic and receptor-mediated cholinergic functions in rat brain. Neurochemical Research, 23, 723-730.
  12. Coskun N. and Büyükuysal L. (1998) Synthesis of 7,12-dihydro-12-phenyl-5H-6,12-methanodibenz[c,f]azocines via N,N-dibenzylphenacylamines. Heterocycles, 48, 53-59.
  13. Gemici K., Kazazoglu A.R., Yesilbursa D., Serdar A., Ener S., Aydinlar A., Büyükuysal L. and Çobanoglu N. (1998) The effects of sublingual administration of captopril on parameters of exercise test and neurohormonal activation in patients with stable angina pectoris. International Journal of Angiology, 7, 238-243.
  14. Büyükuysal R.L and Mete B. (1999) Anoxia-induced dopamine release from rat striatal slices: involvement of reverse transport mechanism. Journal of Neurochemistry, 72, 1507-1515.
  15. Ipekoglu S.Z., Büyükuysal L., Ulus I.H., Korfali E. (2000) Effects of fetal septal grafts on memory and learning performance with acetylcholine and choline metabolism in fimbria transected rats. Journal of Neural Transmission, 102, 191-203.
  16. Büyükuysal R.L. and Mogol E. (2000) Synthesis and release of dopamine in rat striatal slices: requirement for exogenous tyrosine in the medium. Neurochemical Research, 25, 533-540.
  17. Alkan T, Kahveci N., Büyükuysal L, Korfali E., Ozluk K. (2001) Nevroprotective effects of MK801 and hypotermia used alone and in combination in hypoxic-ischemic brain injury in neonatal rats. Arch Physiol Biochem. Apr.109 (2): 135-144.
  18. Büyükuysal RL.(2004) Ischemia and reoxygenation induced amino acid release and tissue damage in the slices of rat corpus striatum. Amino Acids. 27(1): 57-67.
  19. Basagan-Mogol E, Buyukuysal RL, Korfali G. (2004) Effects of ketamine and thiopental on ischemia reoxygenation-induced LDH leakage and amino acid release from rat striatal slices. J Neurosurg Anesthesiol. 17(1): 20-6.
  20. Büyükuysal RL. (2005) Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage. Neurochem Int. 47: 580-8.
  21. Gurbuz O., Gocmen D., Dagdelen F., Gursoy M., Aydin S., Sahin I., Buyukuysal L., Usta M. (In press) Determination of flavan-3-ols and trans-resveratrol in grapes and wine using HPLC with fluorescence detection. Food Chemistry.

 

KİTAP BÖLÜMLERİ

  • Büyükuysal L. Tüberküloz ilaçları toksisitesi ve direnç. Edit. Özyardımcı N., Akciğer ve Akciğer Dışı Organ Tüberkülozları, cilt 3, pp. 176-195, Uludağ Üniversitesi Basımevi, Bursa, 1999
  • Büyükuysal L. Nikotinin Farmakolojisi, Edit. Özyardımcı N., Sigara ve Sağlık, pp. 93-111, Bursa, 2002.
  • Büyükuysal L. Sigara ve İlaç Etkileşmeleri. Edit. Özyardımcı N., Sigara ve Sağlik, pp. 111-123, Bursa 2002.