Prof. Dr. ismail Hakkı ULUS - UÜTF Tıbbi Farmakoloji Anabilim Dalı

Akademik Kadro - Prof. Dr. İsmail Hakkı ULUS

Pozisyonu

Prof. Dr. ismail Hakkı ULUSProfesör
Uludağ Üniversitesi Tıp Fakültesi
Farmakoloji ve Klinik Farmakoloji Anabilim Dalı
Görükle Kampüsü, Bursa, 16059


Tel : +90 (224) 295 3561
Faks : +90 (224) 442 81 02
Email:

 

İLGİLENDİĞİ ARAŞTIRMA ALANLARI

  • Kolinerjik Nörofarmakoloji
  • Semapatik Sistem Uyarılmasi ve Düzenlenmesi
  • Nöroendokrin Düzenleme

 

Üyelİklerİ

  • Türk Farmakoloji Derneği
  • TUBA (Türkiye Bilimler Akademisi)
  • IBRO (International Brain Research Organization)
  • Society for Neuroscience (U.S.A.)

 

YABANCI DİL

  • İngilizce

 

ÖDÜLLERİ

  • (1986) NOVARTIS Farmakoloji Dalı Araştırma Ödülü
    Birincilik Ödülü
  • (1987) NOVARTIS Farmakoloji Dalı Araştırma Ödülü
    Ikincilik Ödülü
  • (1988) NOVARTIS Farmakoloji Dalı Araştırma Ödülü
    Birincilik Ödülü
  • (1997-1998) NOVARTIS Farmakoloji Dalı Araştırma Ödülü
    Birincilik Ödülü
  • (1999) TUBITAK Ödülü
  • (2002-2003) NOVARTIS Farmakoloji Dalı Araştırma Ödülü
    Birincilik Ödülü

 

BAŞLICA YAYINLARI

  1. Ulus IH, Kiran BK (1975) The effect of 6-hydroxydopamine on the tolerance development to the hyperthermic effect of (+)-amphetamine in the rat. J. Pharm. Pharmacol., 27: 205-206.
  2. Ulus IH, Kiran BK, Ozkurt S (1975) Involvement of central dopamine in the hyperthermia in rats produced by d-amphetamine. Pharmacology, 13: 309-316.
  3. Ulus IH, Wurtman RJ (1976) Choline administration: activation of tyrosine hydroxylase in dopaminergic neurons of rat brain. Science, 194: 1060-1061.
  4. Ulus IH, Hirsch MJ, Wurtman RJ (1977) Trans-synaptic induction of adreno-medullary tyrosine hydroxylase activity by choline: Evidence that choline administration an increase cholinergic transmission. Proc. Natl. Acad. Sci., 74: 798-800.
  5. Ulus IH, Scally MC, Wurtman RJ (1977) Choline potentiates the trans-synaptic induction of adrenal tyrosine hydroxylase by reserpine, probably by enhancing the release of acetylcholine. Life Sci., 21: 145-148.
  6. Ulus IH, Meyer E Jr., Wurtman RJ, Ltyle LD (1977) Trans-synaptic induction of adrenal tyrosine hydroxylase following amphetamine treatment in the rat. Neuropharmacology, 16: 635-637.
  7. Scally MC, Ulus IH, Wurtman RJ (1977) Brain tyrosine level controls striatal dopamine synthesis in haloperidol treated rats. J. Neural Transm., 41: 1-6.
  8. Scally MC, Ulus IH, Wurtman RJ (1977) Choline administration to the rat increases urinary catecholamines. J. Neural Transm., 43: 103-112.
  9. Ulus IH, Scally MC, Wurtman RJ (1978) Enhancement by choline of the induction of adrenal tyrosine hydroxylase by phenoxybenzamine, 6- hydroxydopamine, insulin or exposure to cold. J. Pharmacol. Exp. Ther., 204: 676- 682.
  10. Scally MC, Ulus IH, Wurtman RJ, Pettibone JD (1978) Regional distribution of neuro-transmitter synthesizing enzymes and Substance P within the rat corpus striatum. Brain Res., 143: 556- 560.
  11. Pettibone DJ, Kaufman N, Scally MC, Meyer E.Jr., Ulus I, Lytle LD (1978) Striatal nondopaminergic neurons: possible involvement in feeding and drinking behavior. Science, 200: 1175-1177.
  12. Ulus IH, Wurtman RJ (1979) Selective response of rat peripheral sympathetic nervous system to various stimuli. J. Physiol (London), 293: 513- 523.
  13. Ulus IH, Wurtman RJ (1987) Choline increases acetylcholine release. Lancet, 329(8533): 624.
  14. Ulus IH, Wurtman RJ (1988) Prevention by choline of the depletion of membrane phosphatidylcholine by a cholinesterase inhibitor. N. Engl. J. Med., 318: 191.
  15. Ulus I H, Millington WR, Buyukuysal RL, Kiran BK (1988) Choline as an agonist: Determination of its agonistic potency on cholinergic receptors. Biochem. Pharmacol., 37: 2747-2755.
  16. Korfali E, Doygun M, Ulus IH, Rakunt C, Aksoy K (1988) Effects of neuronotrophic factors on adrenal medulla grafts implanted into adult rat brain. Neurosurgery, 22: 994-998.
  17. Ulus IH, Wurtman RJ, Mauron C, Blusztajn JK (1989) Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum. Brain Res., 484: 217-227.
  18. Korfali E, Knowles WD, Uysal S, Ulus IH, Ozmen T (1989) The effect of fetal substantia nigra grafts on dopamine receptors in the corpus striatum. Cleve. Clin. J. Med., 56: 259-262.
  19. Wurtman RJ, Blusztajn JK, Ulus IH, Coviella IL, Buyukuysal RL, Growdon JH, Slack BH (1990) Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases. Adv. Neurol., 51: 117-125.
  20. Blusztajn JK, Growdon JH, Lee H-C, Liscovitch M, Logue M, Lopez G-Coviella I, Mauron C, Richardson UI, Ulus I, Wurtman RJ (1990) Abnormal phospholipid turnover and pathophysiology of Alzheimer's disease. Bull. Clin. Neurosci., 55: 91-98.
  21. Ozcan O, Ulus IH, Yurtkuran M, Karakaya M (1991) Release of vasopressin, cortisol and beta-endorphin in tetraplegic subjects in response to head-up tilt. Paraplegia, 29: 120-124.
  22. Arslan BY, Ulus IH, Savci V, Kiran BK (1991) Effect of intraventricular injected choline on cardiovascular functions and sympathoadrenal activity. J. Cardiovasc. Pharmacol., 17: 814-821.
  23. Johnson DA, Ulus IH, Wurtman RJ (1992) Caffeine potentiates the enhancement by choline of striatal acetylcholine release. Life Sci., 51: 1597-1601.
  24. Ulus IH, Buyukuysal LR, Wurtman RJ (1992) N-Methyl-D-aspartate increases acetylcholine release from rat striatum and cortex: Its effect is augmented by choline. J. Pharmacol. Exp. Ther., 261: 1122-1128.
  25. Yurtkuran, M, Ulus IH, Irdesel FJ (1993) The effect of bolneotyherapy on the plasma b-endorphin level in patients with osteoarthritis. Phys. Rehab. Kur. Med., (?): 130-132.
  26. Buyukuysal LR, Ulus IH, Aydin S, Kiran BK (1995) 3,4-Diaminopyridine and choline increase acetylcholine release in rat striatum. Eur. J. Pharmacol., 281: 179-185.
  27. Ulus IH, Arslan BY, Savci V, Kiran BK (1995) Restoration of blood pressure by choline treatment in rats made hypotensive by haemorrhage. Br. J. Pharmacol., 116: 1911-1917.
  28. Savci V, Gurun S, Ulus IH, Kiran BK (1996) Intraventricular injection of choline increases plasma oxytocin levels in conscious rats. Brain Res., 709: 97-102.
  29. Savci V, Gurun S, Ulus IH, Kiran BK (1996) Effect of intraventricularly injected choline on plasma ACTH and beta-endorphin levels in conscious rats. Eur. J. Pharmacol., 309: 275-280.
  30. Savci V, Ulus IH (1996) Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: the role of vasopressin. Eur. J. Pharmacol., 311: 153-161.
  31. Ulus IH, Wurtman RJ (1997) Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices. J. Pharmacol. Exp. Ther., 281: 149-154.
  32. Savci V, Ulus IH (1997) Cardiovascular effects of central choline during endotoxin shock in the rat. J. Cardiovascular. Pharmacol., 30: 667-675.
  33. Gurun S, Savci V, Ulus IH (1997) Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy. J. Auton. Pharmacol., 17: 155-163.
  34. Gurun S, Savci V, Ulus IH, Kiran BK (1997) Centrally administered choline increases plasma prolactin levels in conscious rats. Neurosci. Lett., 232: 79-82.
  35. Buyukuysal RL, Ulus IH, Kiran BK (1998) Age-related alterations in pre-synaptic and receptor-mediated cholinergic functions in rat brain. Neurochem. Res., 23: 723-730.
  36. Ulus IH, Ozyurt G, Korfali E (1998) Decreased serum choline concentrations in humans after surgery, childbirth and traumatic head injury. Neurochem. Res., 23: 731-736.
  37. Savci V, Ulus IH (1998) Choline administration reverses hypotension in spinal cord transected rats: the involvement of vasopressin. Neurochem. Res., 23: 737-745.
  38. Savci V, Gurun S, Cavun S, Ulus IH (1998) Cardiovascular effects of centrally injected tetrahydroaminoacridine in conscious normotensive rats. Eur. J. Pharmacol., 346: 35-41.
  39. Unal CB, Ulus IH (1998) The effects of choline on body temperature in conscious rats. Eur. J. Pharmacol., 363: 121-126.
  40. Maher TJ, Ulus IH, Wurtman RJ (1999) Phentermine and other monoamine-oxidase inhibitors may increase plasma serotonin when given with fenfluramines. Lancet, 353(9146): 38.
  41. Maher TJ, Ulus IH, Wurtman RJ (1999) Does phentermine inhibit monoamine oxidase? Lancet, 353(9161): 1362-1363.
  42. Wurtman RJ, Maher TJ, Ulus IH (1999) Valvulopathy or primary pulmonary hypertension as possible consequences of administering a serotonin uptake blocker with a monoamine oxidase inhibitor ("Phen-Fen"). Cardiovasc. Res. Rev., 20: 312-314.
  43. Ulus IH, Maher TJ, Wurtman RJ (2000) Characterization of phentermine and related compounds as Monoamine Oxidase (MAO) inhibitors. Biochem. Pharmacol., 59: 1611-1621.
  44. Wurtman RJ, Regan M, Ulus I, Yu L (2000) Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem. Pharmacol., 60: 989-992.
  45. Ipekoglu SZ, Buyukuysal L, Ulus IH, Korfali E (2000) Effects of fetal septal grafts on memory and learning performance with hippocampal acetylcholine and choline metabolism in fimbria transected rats. J. Neural Transm., 107: 191-202.
  46. Isbil-Buyukcoskun N, Gulec G, Ozluk K, Ulus IH (2001) Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline. Braz. J. Med. Biol. Res., 34: 815-820.
  47. Savci V, Cavun S, Gurun MS, Ulus IH (2001) Reversal of haemorrhagic shock in rats by tetrahydroaminoacridine. Pharmacology, 62: 36-44.
  48. Savci V, Goktalay G, Ulus IH (2002) Intracerebroventricular choline increases plasma vasopressin and augments plasma vasopressin response to osmotic stimulation and hemorrhage. Brain Res., 942: 58-70.
  49. Savci V, Cavun S, Goktalay G, Ulus IH (2002) Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: the involvement of cholinergic system. Naunyn Schmiedeberg’s Arch. Pharmacol., 365 (5): 388-398.
  50. Ilcol YO, Dilek K, Yurtkuran M, Ulus IH (2002) Changes of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patients. Clin. Biochem., 35: 233-239.
  51. Ilcol YO, Donmez O, Yavuz M, Dilek K, Yurtkuran M, Ulus IH (2002) Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults. Clin. Biochem., 35: 307-313.
  52. Ozarda Ilcol Y, Ozyurt G, Kilicturgay S, Uncu G, Ulus IH (2002) The decline in serum choline concentration in humans during and after surgery is associated with the elevation of cortisol, adrenocorticotropic hormone, prolactin and beta-endorphin concentrations. Neurosci Lett., 324: 41-44.
  53. Gurun MS, Ilcol YO, Taga Y, Ulus IH (2002) Hyperglycemia induced by intracerebroventricular choline: involvement of the sympatho-adrenal system. Eur J. Pharmacol., 438: 197-205.
  54. Ozarda Ilcol Y, Uncu G, Ulus IH (2002) Free and phospholipid-bound choline concentrations in serum during pregnancy, after delivery and in newborns. Arch. Physiol. Biochem., 110: 393-399.
  55. Ilcol YO, Gurun MS, Taga Y, Ulus IH (2002) Intraperitoneal administration of choline increases serum glucose in rat: involvement of the sympathoadrenal system. Horm. Metab. Res., 34: 341-347.
  56. Savci V, Goktalay G, Cansev M, Cavun S, Yilmaz MS, Ulus IH (2003) Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation. Eur. J. Pharmacol., 468: 129-139.
  57. Ilcol YO, Gurun MS, Taga Y, Ulus IH (2003) Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated aceylcholine release from the rat minced pancreas in vitro. Eur. J. Biochem., 270: 991-999.
  58. Ilcol YO, Yilmaz Z, Ulus IH (2003) Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs. Neurosci Lett., 339: 195-198.
  59. Richardson UI, Watkins CJ, Pierre C, Ulus IH, Wurtman RJ (2003) Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells. Brain Res., 971: 161-167.
  60. Gurun MS, Millington WR, Ulus IH (2003) Choline potentiates the pressor response evoked by glycyl-glutamine or naloxone in haemorrhaged rats. Clin. Exp. Pharmacol. Physiol., 30: 640-642.
  61. Cavun S, Savci V, Ulus IH (2004) Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation. Fundam. Clin. Pharmacol., 18: 71-77.
  62. Ilcol YO, Uncu G, Goren S, Sayan E, Ulus IH (2004) Declines in serum free and bound choline concentrations in humans after three different types of major surgery. Clin. Chem. Lab. Med., 42: 1390-1395.
  63. Kilic SS, Kezer EY, Ilcol YO, Yakut T, Aydin S, Ulus IH (2005) Vitamin A deficiency in patients with common variable immunodeficiency. J. Clin. Immunol., 25: 275-280.
  64. Ilcol YO, Ozbek R, Hamurtekin E, Ulus IH (2005) Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk. J. Nutr. Biochem., 16: 489-499.
  65. Yilmaz Z, Ilcol YO, Ulus IH (2005) Investigation of diagnostic importance of platelet closure times measured by Platelet Function Analyzer-PFA 100 in dogs with endotoxemia. Berl. Munch. Tierarztl. Wochenschr., 118: 341-348.
  66. Ilcol YO, Yilmaz Z, Ulus IH (2005) Endotoxin alters serum-free choline and phospholipid-bound choline concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs. Shock, 24: 288-293.
  67. Yilmaz Z, Ilcol YO, Torun S, Ulus IH (2006) Intravenous administration of choline or CDP-choline improves platelet count and platelet closure times in endotoxin-treated dogs. Shock, 25: 73-79.
  68. Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G. (2006) Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res. 1088(1):83-92.
  69. Ulus IH, Watkins CJ, Cansev M, Wurtman RJ. (In press) Cytidine and uridine increase striatal CDP-Choline levels without decreasing acetylcholine Synthesis or Release. Cell Mol Neurobiol.

 

KİTAP BÖLÜMLERİ

  1. Ulus IH, Wurtman, RJ, Scally MC, Hirsch MJ. Effect of choline on cholinergic function. In: Cholinergic Mechanism and Pyschopharmacology, Ed: D. J. Jenden, Plenum Press, New York, 1977, pp. 525-538.
  2. Ulus IH, Arslan Y, Tanrisever R, Kiran BK. Postsynaptic effects of choline administration. In: Nutrition and the Brain, Vol 5, Eds: A. Barbeau, J.H. Growdon, R.J. Wurtman, Raven Press, New York, 1979, pp. 219-225.
  3. Ulus IH, Ozyurt G, Kavakli B, Kiran BK. Effect of hypoxia on tyrosine hydroxylase activity. In: Neurochemistry and Clinical Neurology, Progress in Clinical and Biological Research, Vol 39, Eds: L. Battistin. G. Hashim, A. Lajtha, Alan R. Liss Inc., New York, 1980, pp. 488.
  4. Ulus IH, Tanrisever R, Kiran BK. Effect of choline on the cholinergic activity. In: Neurochemistry and Clinical Neurology, Progress in Clinical and Biological Research, Vol 39, Eds: L. Battistin. G. Hashim , A. Lajtha, Alan R. Liss, Inc., New York, 1980, pp. 489.
  5. Wurtman RJ, Blusztajn JK, Growdon JH, Ulus IH. Cholinesterase inhibitors increase the brain's need for free choline. In: Current Research in Alzheimer Therapy, Eds: E. Giacobini, R. Becker, Taylor & Francis, 1988, pp. 95-100.
  6. Wurtman RJ, Ulus IH, Blusztajn JK, Logue M, Growdon JH. Development of cholinergic agents for dementia: Relevance of their effects on acetylcholine and phosphatidylcholine synthesis. In: Mental Decline of Elderly People, Eds: A. Agnoli, G. Bruno, Rome, 1990, pp. 1-12.
  7. Blusztajn JK, Liscovitch M, Mauron C, Richardson UI, Ulus IH, Wurtman, RJ. Phosphatidylcholine as a necessary component of biological membranes and as store of choline for acetycholine synthesis. In: Phospholipid in the Nervous System: Biochemical and Molecular Pathology, Fidia Reserach Series, Vol 17, Eds: N.G. Bazan, L.A. Horrocks, G. Toffana, Liviana Press, Padova, 1989, pp. 205-215.
  8. Slack, B., Ulus, I. H., Wurtman, R. J. : Experimental manipulation of phospholipid content in neuronal cell membrane. In: Neurochemical Aspects of Phospholipid Metabolism, Fidia Research Series, Vol 20, Eds: L. Freysz, J. N. Hawthorne, G. Toffano, Liviana Press, Padova, 1989, pp. 233-239.
  9. Wurtman RJ, Ulus IH, Blusztajn KJ, Lopez G-Coviella I, Logue M, Mauron C, Growdon JH. Choline levels, the regulation of acetylcholine and phosphatidylcholine synthesis, and Alzheimer's disease. In: Alzheimer's Disease: Epidemiology, Neuropathology, Neurochemistry and Clinics, Eds: K. Maurer, P. Riederer, H. Beckmann, Springer Verlag, Vienna, 1990, pp. 211-224.
  10. Wurtman RJ, Ulus IH, Mauron C, Blusztajn KJ. Use of choline in cholinergic neurons to form acetylcholine or phosphatidylcholine: Implications for the pathogenesis of age-related memory disorder. In: Aging Brain and Dementia: New Trends in Diagnosis and Therapy, Alan R. Riss, Inc., New York, 1990, pp. 215-238.
  11. Blusztajn JK, Lee HC, Growdon JH, Logue M, Liscovitch M, Lopez G-Coviella I, Mauron C, Richardson UI, Wurtman RJ, Ulus IH. Abnormal phospholipid metabolism and the pathophysiology of Alzheimer's disease. In: Alzheimer's Disease New Treatment Strategies, Eds: Z.S. Khachaturian, J. P. Blass,Marcell Dekker, Inc., New York, 1992, pp. 213-222.
  12. Kiran BK, Ulus IH. Selective response of rat peripheral sympathetic nervous system to various stress situations. In: Stress: Neuroendocrine and Molecular Approaches, Eds: R. Kvetnansky, R. McCarty, J. Axelrod, Gordon and Breach Science Publishers S.A., New York, 1992, pp. 561- 568.