RESEARCH FACILITIES

The department has the following research laboratories and facilities:

1) General Laboratory: This laboratory is equipment for basic laboratory research and provides several systems for in vitro studies. Tissue perfusion systems (mainly for brain slices), tissue chopper, tissue homogenizators, spectrophotometer, spectrophotofluorometer, pH meter are the main equipment in this laboratory.

2) HPLC Laboratory: Current research activities in this laboratory include both determination and measurement of endogenous molecules and drugs in biological samples. Capillary electrophoresis, gas chromatography-mass spectroscopy (GC-MS), isocratic and gradient HPLC pumps, several detectors (U.V. florescent, diodaray, electrochemical, F.A.D.), post-column derivatization unit are basic instruments in this laboratory. Choline, acetylcholine and other choline derivatives, adrenaline, noradrenaline, dopamine, amino acids, several vitamins are some of the compounds that determined currently by the graduate students.

3) Pain Mechanisms Laboratory: This laboratory was equipped to perform the specific studies about on pain and analgesia. Thermal Plantar Analgesy Meter (Hargreaves test), Dynamic Plantar Aesthesiometer,  Randall-Selitto Analgesy Meter, Hot Plate, Tail Flick, Manuel Von-Frey Ligaments, Rota Rod Tread mils are the basic instruments of this laboratory.

4) Cardiovascular Hemodynamics Laboratory: This laboratory has been designed to perform long term chronic and acute cardiovascular hemodynamic studies. Basic instruments are poligraph, MP 100 data acquisition system. Poligraph system can be used for simple measurement of blood pressure and heart rate of animals. However MP 100 system allows to record and analyze data from a variety of subjects, both human and animal. The acknowledge software provides tools for on-line, beat-by-beat analysis, in addition to post acquisition processing. In addition to blood pressure measurement, perfusion rate of specific tissues can be analyzed by using Doppler flow probes and amplifier units.

5) Microdialysis Laboratory: Designed for microdialysis of several brain areas of freely moving or anesthetized laboratory animals. This method provides collection of the extracellular fluid from the investigated brain area and thus allows to determine the endogenous substances that released from the nerve endings.

6) Psychopharmacology Laboratory: This laboratory has been design to perform behavioral studies . Basic instruments are acoustic startle reflex measurement system, open field locomotor activity system and video tracking system. With those system it is possible measure several behavioral tests such as prepulse inhibition, locomotor activity, conditioned place preference, plus maze, object recognition, and social interaction test.

7) Radioimmunoassay (RIA) Laboratory: Designed according to rules of National Radiation Protection Office and allows to study with radioactive materials in research studies and included gamma and beta counters and other related equipment.

8) Cell Culture Laboratory: Designed for research on selective cell culture (such as neuroblastoma) and includes laminal airflow, CO2 incubator and related chemicals.

9) Molecular Biology Laboratory: Designed for molecular biology and pharmacogenetic studies. Thermal cycler, ultraviolet crosslinker, vertical and horizontal gel electrophoresis are the basic laboratory apparatus.